This study examined differences in the quantity of child vocalizations (CVs) between preschool and home environments using the Language Environmental Analysis (LENA). The sample included monolingual English-speaking children (n = 27) and Spanish–English speaking dual language learners (n = 30). A two-way mixed effects analysis of variance with one between-subjects effect (language) and one within-subjects effect (setting) was conducted to examine whether there was a significant difference in CVs between home and school settings, and whether that contrast differentially affected monolingual and English language learner (ELL) preschool participants. Overall, there was a significant difference in average hourly CVs between home and preschool environments with a higher rate of CV at home than at school for both monolinguals and ELLs. Results support the need to carefully consider the environment in communication sampling, recognizing that child vocalization counts (CVCs) may vary by environment.